Endoplasmic reticulum stress and endothelial dysfunction
نویسندگان
چکیده
منابع مشابه
Endoplasmic Reticulum Stress and Microvascular Endothelial Dysfunction in Diabetes
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia, due to deficiency in insulin or insulin resistance, and represents a major cause of morbidity and mortality in contemporary societies [1,2]. According to the world health organization (WHO), more than 285 million people worldwide suffered from diabetes of which 4 million died in 2010. The prevalence is expected to ...
متن کاملEndothelial cells, endoplasmic reticulum stress and oxysterols
Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis. Mounting evidence linked the atherosclerosis to endothelium dysfunction; in fact, the endothelium regulates the vascular system with roles in processes such as hemostasis, cell cholesterol, hormone trafficking, signal transduct...
متن کاملAsymmetric Dimethylarginine Induced Apoptosis and Dysfunction of Endothelial Progenitor Cells: Role of Endoplasmic Reticulum Stress Pathway
Asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide synthase, is a novel risk factor of cardiovascular disease. Endothelial progenitor cells (EPCs) bear typical endothelial characteristics and are thought to contribute to neovascularization by providing new endothelial cells (ECs) after arterial injury. Many studies have shown that ADMA can induce EPC apoptosis and dysfunction, but...
متن کاملHomocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress
Homocysteine- (Hcy-) induced endothelial cell apoptosis has been suggested as a cause of Hcy-dependent vascular injury, while the proposed molecular pathways underlying this process are unclear. In this study, we investigated the adverse effects of Hcy on human umbilical vein endothelial cells (HUVEC) and the underlying mechanisms. Our results demonstrated that moderate-dose Hcy treatment induc...
متن کاملEndoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice.
OBJECTIVE Cardiac damage and vascular dysfunction are major causes of morbidity and mortality in hypertension. In the present study, we explored the beneficial therapeutic effect of endoplasmic reticulum (ER) stress inhibition on cardiac damage and vascular dysfunction in hypertension. METHODS AND RESULTS Mice were infused with angiotensin II (400 ng/kg per minute) with or without ER stress i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IUBMB Life
سال: 2014
ISSN: 1521-6543
DOI: 10.1002/iub.1292